Hydrochloric Acid → 2,6-Difluoro-3-nitrobenzoic acid

HRID 1187294ノート

反応式

HRID 1187294 の反応式
C([O:8][C:9](=[O:21])[C:10]1[C:15]([F:16])=[CH:14][CH:13]=[C:12]([N+:17]([O-:19])=[O:18])[C:11]=1[F:20])C1C=CC=CC=1.[OH-].[Na+].Cl>O1CCCC1.O>[F:20][C:11]1[C:12]([N+:17]([O-:19])=[O:18])=[CH:13][CH:14]=[C:15]([F:16])[C:10]=1[C:9]([OH:21])=[O:8]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 583170052,6-Difluoro-3-nitro-benzoic acid benzyl ester

生成物 1

HCID 3026292,6-Difluoro-3-nitrobenzoic acid収率 56.8%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To 2,6-difluoro-3-nitro-benzoic acid benzyl ester (47, 750 mg, 2.6 mmol) in 4 mL of tetrahydrofuran and 2 mL of water, sodium hydroxide (0.2 g, 5.0 mmol) is added and the reaction is stirred for 2 hours. The reaction is acidified with dilute hydrochloric acid and extracted with ethyl acetate. The organic layer is concentrated under vacuum to provide the desired compound (48, 300 mg).

後処理

  1. extractionextracted with ethyl acetate
  2. concentrationThe organic layer is concentrated under vacuum

出典と根拠

ORDレコード
ord-c579b3f9030948b38928ca0b846d3113
出典データセット
uspto-grants-2014_03
特許番号
US08673928B2

反応ノート

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