HCID 59408784、化合物 → HCID 25001115、化合物

HRID 1188128ノート

反応式

HRID 1188128 の反応式
[CH3:1][N:2](C1CCCCO1)[C:3]1[S:4][C:5]([CH2:8][NH:9][C:10]2[S:11][CH:12]=[CH:13][N:14]=2)=[CH:6][N:7]=1>C(O)(C(F)(F)F)=O.C(Cl)(Cl)Cl>[CH3:1][NH:2][C:3]1[S:4][C:5]([CH2:8][NH:9][C:10]2[S:11][CH:12]=[CH:13][N:14]=2)=[CH:6][N:7]=1

参加物

4

反応物 1

HCID 59408784HCID 59408784、化合物

生成物 1

HCID 25001115HCID 25001115、化合物収率 77.3%

試薬・触媒・溶媒 2

HCID 6212Chloroform溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of N-methyl-N-(tetrahydro-2H-pyran-2-yl)-5-((thiazol-2-ylamino)methyl) thiazol-2-amine (50 mg, 0.16 mmol) in 10% TFA in CHCl3 (5 mL) was stirred at RT overnight. After evaporating the solvent, the residue was dissolved in MeOH, neutralized with Na2CO3 and extracted with CHCl3. The organic phase was dried, concentrated and purified by column chromatography yielding N-methyl-5-((thiazol-2-ylamino)methyl)thiazol-2-amine (28 mg, 77%) as a solid.

後処理

  1. customAfter evaporating the solvent
  2. dissolutionthe residue was dissolved in MeOH
  3. extractionextracted with CHCl3
  4. customThe organic phase was dried
  5. concentrationconcentrated
  6. custompurified by column chromatography

出典と根拠

ORDレコード
ord-a27ef617d8964f4891dd1b840f4bca0b
出典データセット
uspto-grants-2014_03
特許番号
US08673940B2

反応ノート

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