Iodoethane → 3-(3,5-Difluorophenyl)-1-ethyl-3-methoxypyrrolidine

HRID 1188163ノート

反応式

HRID 1188163 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:9]2([O:14][CH3:15])[CH2:13][CH2:12][NH:11][CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:16](N(CC)CC)[CH3:17].ICC>O1CCCC1.CO>[F:1][C:2]1[CH:3]=[C:4]([C:9]2([O:14][CH3:15])[CH2:13][CH2:12][N:11]([CH2:16][CH3:17])[CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1

参加物

6

反応物 3

HCID 6340IodoethaneHCID 8471TriethylamineHCID 199358743-(3,5-Difluorophenyl)-3-methoxypyrrolidine

生成物 1

HCID 462192253-(3,5-Difluorophenyl)-1-ethyl-3-methoxypyrrolidine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of (+)-3-(3,5-difluorophenyl)-3-methoxypyrrolidine (0.01 g, 0.047 mmol) and triethylamine (13.1 μL, 0.0938 mmol) in tetrahydrofuran (3 ml), was added iodoethane (5.6 μL, 0.070 mmol). The resulting mixture was stirred at ambient temperature for 24 h and then diluted with methanol and analyzed by GCMS and LCMS. Analysis show 64% conversion. MS m/z (relative intensity, 70 eV) 241 (M+, 10), 226 (86), 211 (33), 141 (49), 71 (bp).

出典と根拠

ORDレコード
ord-536c84e5ce7c4ec596d4f684cfe77cdb
出典データセット
uspto-grants-2014_03
特許番号
US08673962B2

反応ノート

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