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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0

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反応

Hydrochloric Acid → 8-methyl-4-oxo-1-(tetrahydro-2H-thiopyran-4-ylmethyl)-4,5-dihydro[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid

HRID 1189445

印刷プレビュー

反応式

HRID 1189445 の反応式

Cl[C:2]1[C:3]2[N:4]([C:17]([CH2:20][CH:21]3[CH2:26][CH2:25][S:24][CH2:23][CH2:22]3)=[N:18][N:19]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][C:8]([C:12]([O:14]C)=[O:13])=[C:7]([CH3:16])[CH:6]=2.[O:27]1CCCC1.[OH-].[Na+].Cl>CO>[CH3:16][C:7]1[CH:6]=[C:5]2[C:10]([NH:11][C:2](=[O:27])[C:3]3[N:4]2[C:17]([CH2:20][CH:21]2[CH2:26][CH2:25][S:24][CH2:23][CH2:22]2)=[N:18][N:19]=3)=[CH:9][C:8]=1[C:12]([OH:14])=[O:13]

参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 313Hydrochloric Acid

HCID 8028Tetrahydrofuran

HCID 14798Sodium Hydroxide

HCID 58575435methyl 4-chloro-8-methyl-1-(tetrahydro-2H-thiopyran-4-ylmethyl)[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylate

生成物 1

HCID 585756078-methyl-4-oxo-1-(tetrahydro-2H-thiopyran-4-ylmethyl)-4,5-dihydro[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度: 60 °C

実験手順

To a mixed liquid of 1.70 g of methyl 4-chloro-8-methyl-1-(tetrahydro-2H-thiopyran-4-ylmethyl)[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylate, 18.0 mL of tetrahydrofuran, and 18.0 mL of methanol was added 9.20 mL of a 3 M aqueous sodium hydroxide solution, followed by stirring at 60° C. overnight. 3 M hydrochloric acid was added thereto to adjust the pH to about 3, and the precipitated solid was collected by filtration and dried under reduced pressure to obtain 1.20 g of 8-methyl-4-oxo-1-(tetrahydro-2H-thiopyran-4-ylmethyl)-4,5-dihydro[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid as a yellow solid.

後処理

filtrationthe precipitated solid was collected by filtration
customdried under reduced pressure

出典と根拠

ORDレコード: ord-ad9c48c9dbc0486fbf5b1ca1679d958d
出典データセット: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08674096B2

反応ノート

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