Citric Acid → HCID 67566730、化合物

HRID 1191970

反応式

HRID 1191970 の反応式
[Na:1].[CH3:2][CH2:3][CH2:4][N:5]([C:9]([CH:11]([NH:17][C:18]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:19])[CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[O:10])[CH2:6][CH2:7][CH3:8].C(CN)O.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O>[Na:1].[CH3:2][CH2:3][CH2:4][N:5]([C:9]([CH:11]([NH:17][C:18]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:19])[CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[O:10])[CH2:6][CH2:7][CH3:8]

参加物

6

反応物 4

HCID 311Citric AcidHCID 700EthanolamineHCID 4922ProglumideHCID 5360545Sodium

生成物 1

HCID 67566730HCID 67566730、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In another embodiment, a composition for IV injection can be made as follows: add 4263 g of the sodium salt of proglumide to 15 L of water and 93 g of ethanolamine and stir until a clear solution is obtained. After buffering with citric acid, the solution is diluted to a volume of 30 L, then filtered under pressure in an inert gas into 40,000 glass vials which are sterilized under heat, yielding 40,000 vials each containing 106.6 mg sodium proglumide, equivalent to 100 mg proglumide.

後処理

  1. customis obtained
  2. additionthe solution is diluted to a volume of 30 L
  3. filtrationfiltered under pressure in an inert gas into 40,000 glass vials which
  4. temperatureunder heat

出典と根拠

ORDレコード
ord-ee737652bf5048daa246a908955b71cd
出典データセット
uspto-grants-2014_03
特許番号
US08680145B1

関連ノート

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