m-Chloroperbenzoic acid → Furo[3,2-b]pyridine 4-oxide
反応式
[O:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.C1C=C(Cl)C=C(C(OO)=[O:18])C=1>C(Cl)(Cl)Cl>[O:1]1[C:9]2[C:4](=[N+:5]([O-:18])[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1参加物
4
実験手順
To a solution of Furo[3,2-b]pyridine (1.5 g, 13.0 mmol) in CHCl3 (30 mL) was added MCPBA (2.9 g, 17.0 mmol). The mixture was stirred at room temperature for 16 hours. Then the mixture was filtered through a alumina (140 g, basic) and washed with ethyl acetate/hexane (1:1) and DCM/MeOH (20:1) to give Furo[3,2-b]pyridine 4-oxide (1.49 g, 88%). 1H NMR (CDCl3, 400 MHz) δ 8.25 (m, 1H), 7.81 (m, 1H), 7.51 (m, 1H), 7.23 (m, 1H).
後処理
- filtrationThen the mixture was filtered through a alumina (140 g, basic)
- washwashed with ethyl acetate/hexane (1:1) and DCM/MeOH (20:1)
出典と根拠
- ORDレコード
- ord-9f3a2bcc15604a0da768bf3018928a71
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08680114B2
反応ノート
読み込み中…