Potassium Carbonate → (1R,6S)-8-(3-Methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane
反応式
FC(F)(F)C1[CH:8]=[CH:7][N:6]=[C:5]([N:9]2[C@@H:16]3[C@@H:11]([CH2:12][CH2:13][NH:14][CH2:15]3)[CH2:10]2)N=1.ClC1N=C(C(F)(F)F)[CH:23]=[CH:22][N:21]=1.C([O-])([O-])=O.[K+].[K+].CCN(C(C)C)C(C)C>C(#N)C.CN(C=O)C>[CH3:23][C:22]1[C:5]([N:9]2[C@@H:16]3[C@@H:11]([CH2:12][CH2:13][NH:14][CH2:15]3)[CH2:10]2)=[N:6][CH:7]=[CH:8][N:21]=1参加物
7
実験手順
The title compound was prepared in a manner analogous to Intermediate 27, substituting 2-chloro-3-methylpyrazine for 2-chloro-4-(trifluoromethyl)pyrimidine. In addition, DMF and K2CO3 at 95° C. was used in place of DIPEA and ACN.
後処理
- customat 95° C.
出典と根拠
- ORDレコード
- ord-288c73417fe44ba1a28da2a9cb500103
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08680275B2
反応ノート
読み込み中…