Sodium hydride → HCID 13013062、化合物
反応式
[Cl-].[CH3:2][S+](C)(C)=O.[H-].[Na+].[H][H].[OH:11][C:12]1[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:13]=1[CH:14]=[O:15]>O1CCCC1.O>[OH:15][CH:14]1[C:13]2[CH:16]=[CH:17][C:18]([CH3:20])=[CH:19][C:12]=2[O:11][CH2:2]1参加物
7
実験手順
To a solution of trimethylsulfoxonium chloride (12.9 g) in tetrahydrofuran (200 ml) was added sodium hydride (2.4 g of 100%). This solution was heated at reflux until hydrogen evolution had ceased. 13.6 g of 2-hydroxy-4-methylbenzaldehyde dissolved in tetrahydrofuran (100 ml) was then added. The reaction mixture was refluxed until the reaction was complete (3 hours). It was then poured into water (600 ml), extracted with ether, the ether dried over sodium sulphate and evaporated to give 3-hydroxy-6-methyl-2,3-dihydrobenzofuran.
後処理
- temperatureThis solution was heated
- additionwas then added
- temperatureThe reaction mixture was refluxed until the reaction
- custom(3 hours)
- extractionextracted with ether
- dry with materialthe ether dried over sodium sulphate
- customevaporated
出典と根拠
- ORDレコード
- ord-16e05b46acfe44c8b47b3c671b1a0282
- 出典データセット
- uspto-grants-1989_03
- 特許番号
- US04816473
反応ノート
読み込み中…