Ethanol → Phenacyl thiocyanate

HRID 1195793ノート

反応式

HRID 1195793 の反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].[S-:11][C:12]#[N:13].[K+].C(O)C>O>[S:11]([CH2:9][C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:2]=1)=[O:10])[C:12]#[N:13]

参加物

5

反応物 3

HCID 702EthanolHCID 750602'-BromoacetophenoneHCID 516872Potassium thiocyanate

生成物 1

HCID 219693Phenacyl thiocyanate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In accordance with the known process (Beilstein, 8, 94), 10.0 g (50 mmol) of o-bromoacetophenone and 4.9 g (50 mmol) of potassium thiocyanate were added to 80 ml of ethyl alcohol, and the resultant mixture was heated at 80° C. for 3 hours and then allowed to stand overnight. Added to the reaction mixture were 50 ml of water. Precipitated crystals were collected by filtration, washed with 50% aqueous ethyl alcohol and then dried, whereby the title compound was obtained as colorless crystals.

後処理

  1. additionAdded to the reaction mixture
  2. customPrecipitated crystals
  3. filtrationwere collected by filtration
  4. washwashed with 50% aqueous ethyl alcohol
  5. customdried

出典と根拠

ORDレコード
ord-89cd3467c1aa4bdf84dd26db3d3a38a0
出典データセット
uspto-grants-1992_05
特許番号
US05112841

反応ノート

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