Methanol → Methyl 2-(2-Aminoacetamido)Acetate

HRID 1196812

反応式

HRID 1196812 の反応式
[NH2:1][CH2:2][C:3]([NH:5][CH2:6][C:7]([OH:9])=[O:8])=[O:4].S(Cl)(Cl)=O.[CH3:14]O>>[NH2:1][CH2:2][C:3]([NH:5][CH2:6][C:7]([O:9][CH3:14])=[O:8])=[O:4]

参加物

4

反応物 3

HCID 887MethanolHCID 11163GlycylglycineHCID 24386Thionyl Chloride

生成物 1

HCID 3248350Methyl 2-(2-Aminoacetamido)Acetate

実験手順

2.5 g (19 mmoles) of Gly-Gly-OH was suspended in 25 mL of dry methanol. Two equivalents of thionyl chloride were added, and the suspension stirred to dissolution. The mixture was allowed to sit at room temperature overnight. The solvent was removed under vacuum, the residue taken up in a minimum of methanol, and anhydrous ether added to effect crystallization. Yield 3.2 g (92%). M.P. 146°-146° C. 1H-NMR (DMSO) 3.6 (s, 3H OMe), 3.8 and 3.9 (d, 2H, Gly α-H's).

後処理

  1. customThe solvent was removed under vacuum
  2. additionadded to effect crystallization

出典と根拠

ORDレコード
ord-fc8851893076401a9a5849d488c88b6c
出典データセット
uspto-grants-1992_05
特許番号
US05116741

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