Thionyl Chloride → 4-(Chloromethyl)-2,5-dimethyloxazole hydrochloride
反応式
[CH3:1][C:2]1[O:3][C:4]([CH3:9])=[C:5]([CH2:7]O)[N:6]=1.S(Cl)([Cl:12])=O>ClC(Cl)Cl>[ClH:12].[Cl:12][CH2:7][C:5]1[N:6]=[C:2]([CH3:1])[O:3][C:4]=1[CH3:9]参加物
4
実験手順
To a solution of 18.5 parts of 2,5-dimethyl-4-oxazolemethanol in 200 parts of trichloromethane there were added dropwise 21.1 parts of thionyl chloride. After stirring for 2 hours at room temperature, the reaction mixture was evaporated and the residue was co-evaporated with methylbenzene, yielding 26.4 parts (100%) of 4-(chloromethyl)-2,5-dimethyloxazole hydrochloride (interm. 26).
後処理
- customthe reaction mixture was evaporated
出典と根拠
- ORDレコード
- ord-88cd125f5cd2406b9903f8649794ed6a
- 出典データセット
- uspto-grants-1994_01
- 特許番号
- US05278165
反応ノート
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