Hydrazine hydrate (1:1) → 4-Phenoxybutan-1-amine

HRID 1198119

反応式

HRID 1198119 の反応式
[O:1]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]1C(=O)C2=CC=CC=C2C1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.NN>C(O)C>[O:1]([CH2:8][CH2:9][CH2:10][CH2:11][NH2:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 166375972-(4-Phenoxybutyl)-1H-isoindole-1,3(2H)-dione

生成物 1

HCID 1162404-Phenoxybutan-1-amine収率 96.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of N-(4-phenoxybutyl)phthalimide (7.8 g), hydrazine hydrate (7 ml) and ethanol (150 ml) was stirred for one hour under reflux. Crystalline precipitate was filtered off, then the filtrate was concentrated under reduced pressure to give 4-phenoxybutylamine (4.2 g, 95%) as an oily product.

後処理

  1. temperatureunder reflux
  2. filtrationCrystalline precipitate was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-43de905befef4fd6a66a6a7f25f015a2
出典データセット
uspto-grants-1994_01
特許番号
US05280022

関連ノート

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