2-Aminopyridine → 2-(2-Bromophenyl)imidazo[1,2-a]pyridine

HRID 1199472

反応式

HRID 1199472 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.Br[CH2:9][C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Br:18])=O>C(O)C>[Br:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[C:10]1[N:1]=[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]2[CH:9]=1

参加物

4

反応物 2

HCID 104392-AminopyridineHCID 27375222-Bromophenacyl Bromide

生成物 1

HCID 28623882-(2-Bromophenyl)imidazo[1,2-a]pyridine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 2-aminopyridine (1.63 g) and 2-bromo-1-(2-bromophenyl)-ethanone (4.8 g) in dry ethanol (40 mls) was heated under reflux for 1 hour. The mixture was concentrated in vacuo. The residue was treated with dilute sodium bicarbonate solution and extracted with ethyl acetate. The ethyl acetate was washed with water and brine then dried and evaporated. Flash chromatography produced the sub-title compound as a light grey oil. MS MW 272/274 bp 272.

後処理

  1. temperatureunder reflux for 1 hour
  2. concentrationThe mixture was concentrated in vacuo
  3. additionThe residue was treated with dilute sodium bicarbonate solution
  4. extractionextracted with ethyl acetate
  5. washThe ethyl acetate was washed with water and brine
  6. customthen dried
  7. customevaporated

出典と根拠

ORDレコード
ord-5dac21755698435cbc12774be3fba360
出典データセット
uspto-grants-1990_02
特許番号
US04900751

関連ノート

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