反応式
C(N(C(C)C)CC)(C)C.[C:10](Cl)(=[O:15])[CH2:11][CH2:12][CH2:13][CH3:14].Cl.Cl.[N:19]1[C:27]2[CH2:26][CH2:25][NH:24][CH2:23][C:22]=2[S:21][C:20]=1[NH:28][C:29]([NH2:31])=[NH:30].[OH-].[Na+]>CN(C)C=O.C(OCC)(=O)C>[C:10]([CH:23]1[C:22]2[S:21][C:20]([NH:28][C:29]([NH2:31])=[NH:30])=[N:19][C:27]=2[CH2:26][CH2:25][NH:24]1)(=[O:15])[CH2:11][CH2:12][CH2:13][CH3:14]参加物
7
実験手順
Diisopropylethylamine (0.22 mmol) and then pentanoyl chloride (0.11 mmol) are added to a stirred suspension of N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine-dihydrochloride (0.1 mmol) in dimethylformamide (0.7 ml) and the reaction mixture is stirred for another 16 hours at room temperature. After the addition of 2M caustic soda solution (1 ml) extraction is carried out with ethyl acetate. The combined organic phases produce the pure title compound after drying over sodium sulphate and concentrating to dryness.
出典と根拠
- ORDレコード
- ord-98496fd20a5141068171bd4a1a3cc0ec
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07727979B2
関連ノート
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