Sodium Hydroxide → HCID 178454398、化合物

HRID 12067ノート

反応式

HRID 12067 の反応式
C(N(C(C)C)CC)(C)C.[CH:10]([CH2:12][C:13]([OH:15])=O)=[CH2:11].N1C2C=CC=C(O[P+](N(C)C)(N(C)C)N(C)C)C=2N=N1.F[P-](F)(F)(F)(F)F.Cl.Cl.[N:45]1[C:53]2[CH2:52][CH2:51][NH:50][CH2:49][C:48]=2[S:47][C:46]=1[NH:54][C:55]([NH2:57])=[NH:56].[OH-].[Na+]>CN(C)C=O>[C:13]([N:50]1[CH2:51][CH2:52][C:53]2[N:45]=[C:46]([NH:54][C:55]([NH2:57])=[NH:56])[S:47][C:48]=2[CH2:49]1)(=[O:15])[CH2:12][CH:10]=[CH2:11]

参加物

7

反応物 5

HCID 14798Sodium HydroxideHCID 327433-Butenoic acidHCID 81531DiisopropylethylamineHCID 178478794HCID 178478794、化合物HCID 178486078HCID 178486078、化合物

生成物 1

HCID 178454398HCID 178454398、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Diisopropylethylamine (0.22 mmol), vinyl acetic acid (0.11 mmol) and benzotriazolyloxy-tris-(dimethylamino)phosphonium-hexafluorophosphate (0.11 mmol) are added successively to a stirred suspension of N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine-dihydrochloride (0.1 mmol) in dimethylformamide (0.7 mL), and the reaction mixture is stirred for 16 hours at room temperature. After the addition of 2M caustic soda solution (1 ml) there is extraction with ethyl acetate. The combined organic phases produce the pure title compound after drying over sodium sulphate and concentrating to dryness.

後処理

  1. extractionextraction with ethyl acetate

出典と根拠

ORDレコード
ord-fecbe090558448a4a06f30a565bfc4fc
出典データセット
uspto-grants-2010_06
特許番号
US07727979B2

反応ノート

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