Tetrahydrofuran → 1-{3-[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-ylthio]phenyl}-3-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea

反応式

[CH2:55]1[O:56][CH2:57][CH2:58][CH2:59]1.[CH3:1][n:2]1[n:3][c:4]([C:17]([F:18])([F:19])[F:20])[cH:5][c:6]1[NH:7][C:8]([O:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)=[O:16].[CH3:21][O:22][c:23]1[cH:24][c:25]2[c:26]([S:38][c:39]3[cH:40][c:41]([NH2:42])[cH:43][cH:44][cH:45]3)[n:27][cH:28][n:29][c:30]2[cH:31][c:32]1[O:33][CH2:34][CH2:35][O:36][CH3:37].[CH:46]([N:47]([CH2:48][CH3:49])[CH:50]([CH3:51])[CH3:52])([CH3:53])[CH3:54]>>[CH3:1][n:2]1[n:3][c:4]([C:17]([F:18])([F:19])[F:20])[cH:5][c:6]1[NH:7][C:8](=[O:16])[NH:42][c:41]1[cH:40][c:39]([S:38][c:26]2[c:25]3[cH:24][c:23]([O:22][CH3:21])[c:32]([O:33][CH2:34][CH2:35][O:36][CH3:37])[cH:31][c:30]3[n:29][cH:28][n:27]2)[cH:45][cH:44][cH:43]1