Water → 7-Hydroxy-6-methoxy-4-(2,3-methylenedioxyanilino)quinazoline

HRID 1241570ノート

反応式

HRID 1241570 の反応式
Cl.C([O:9][C:10]1[CH:19]=[C:18]2[C:13]([C:14]([NH:20][C:21]3[CH:26]=[CH:25][CH:24]=[C:23]4[O:27][CH2:28][O:29][C:22]=34)=[N:15][CH:16]=[N:17]2)=[CH:12][C:11]=1[O:30][CH3:31])C1C=CC=CC=1.C([O-])=O.[NH4+].O>[Pd].CN(C=O)C>[OH:9][C:10]1[CH:19]=[C:18]2[C:13]([C:14]([NH:20][C:21]3[CH:26]=[CH:25][CH:24]=[C:23]4[O:27][CH2:28][O:29][C:22]=34)=[N:15][CH:16]=[N:17]2)=[CH:12][C:11]=1[O:30][CH3:31]

参加物

6

反応物 3

HCID 962WaterHCID 2723923Ammonium formateHCID 219360977-Benzyloxy-6-methoxy-4-(2,3-methylenedioxyanilino)quinazoline hydrochloride

生成物 1

HCID 1355941137-Hydroxy-6-methoxy-4-(2,3-methylenedioxyanilino)quinazoline収率 100.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 7-benzyloxy-6-methoxy-4-(2,3methylenedioxyanilino)quinazoline hydrochloride (21 g), ammonium formate (30.2 g), 10% palladium-on-charcoal catalyst (4.8 g), water (26 ml) and DMF (350 ml) was stirred at ambient temperature for 2 hours. The mixture was filtered and the filtrate was evaporated. The residual oil was triturated under diethyl ether. The solid so obtained was triturated under water, collected by filtration, washed with water and with diethyl ether and dried under vacuum over phosphorus pentoxide. The material so obtained was purified by column chromatography on silica using a 9:1 mixture of methylene chloride and methanol as eluent. There was thus obtained the title compound (15 g); NMR Spectrum: (DMSOd6) 3.95 (s, 3H), 6.0 (s, 2H), 6.85 (m, 2H), 6.95 (d, 1H), 7.05 (s, 1H), 7.8 (s, 1H), 8.3 (s, 1H), 9.4 (s, 1H), 10.3 (s, 1H); Mass Spectrum: M+H+ 312.

後処理

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated
  3. customThe residual oil was triturated under diethyl ether
  4. customThe solid so obtained
  5. customwas triturated under water
  6. filtrationcollected by filtration
  7. washwashed with water and with diethyl ether
  8. dry with materialdried under vacuum over phosphorus pentoxide
  9. customThe material so obtained
  10. customwas purified by column chromatography on silica using
  11. additiona 9:1 mixture of methylene chloride and methanol as eluent

出典と根拠

ORDレコード
ord-11fc6ca0af324211b8e0c0db76b39ee4
出典データセット
uspto-grants-2006_10
特許番号
US07115615B2

反応ノート

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