Sodium Hydroxide → 5-Phenyl-1,2-oxazol-3-amine

HRID 1241596ノート

反応式

HRID 1241596 の反応式
[C:1]1([C:7]#[C:8][C:9]#[N:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:12][OH:13].[OH-].[Na+]>CCO.O>[NH2:10][C:9]1[CH:8]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[O:13][N:12]=1

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 963823-Phenyl-2-propynenitrileHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 36207925-Phenyl-1,2-oxazol-3-amine

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a stirred solution of 3-phenyl-2-propyne-nitrile (1.27 g, 0.01 mol, Step A) in EtOH (20 mL) was added at RT hydroxylamine hydrochloride (3.5 g, 0.05 mol) followed by 10% NaOH (28 mL). The exothermic reaction was stirred at RT 24 h, then diluted with H2O. The resulting precipitate was filtered off, washed with H2O and dried over P2O5 to afford 3-amino-5-phenylisoxazole as a white crystalline solid.

後処理

  1. customThe exothermic reaction
  2. filtrationThe resulting precipitate was filtered off
  3. washwashed with H2O
  4. dry with materialdried over P2O5

出典と根拠

ORDレコード
ord-2e390789c1c84e09a7cf468793ca3451
出典データセット
uspto-grants-2006_10
特許番号
US07115617B2

反応ノート

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