Methyl iodide → Diphenoxymethane

HRID 1243962

反応式

HRID 1243962 の反応式
[O:1]([C:8]1C=CC(O)=CC=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:15][C:16](C)([O-:18])[CH3:17].[K+].CI.[CH2:23]1[CH2:27]OC[CH2:24]1>>[O:18]([CH2:8][O:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:16]1[CH:17]=[CH:27][CH:23]=[CH:24][CH:15]=1

参加物

5

反応物 4

HCID 6328Methyl iodideHCID 8028TetrahydrofuranHCID 132544-PhenoxyphenolHCID 23665647Potassium tert-butoxide

生成物 1

HCID 78183Diphenoxymethane

実験手順

4-(Phenoxy)phenol (9.31 g, 50 mmol) in THF (100 mL) was treated with potassium t-butoxide (6.17 g, 55 mmol) at room temperature for 10 min. Methyl iodide (7.87 g, 55 mmol) was added by syringe. After stirring for 18 h at room temperature the reaction was quenched with saturated ammonium chloride solution and diluted with ethyl ether. The separated organic layer was washed with saturated ammonium chloride solution, dried with magnesium sulfate, filtered and concentrated to give 9.98 g of the title compound as a pale yellow oil. GS-MS (m/z, EI): 200 [M]+.

後処理

  1. customwas quenched with saturated ammonium chloride solution
  2. additiondiluted with ethyl ether
  3. washThe separated organic layer was washed with saturated ammonium chloride solution
  4. dry with materialdried with magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-191aa6473abc48819fccfa42a9fa38cc
出典データセット
uspto-grants-2006_10
特許番号
US07119201B2

関連ノート

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