Erythrose, 4-phosphate → D-erythritol 4-phosphate

HRID 1244185ノート

反応式

HRID 1244185 の反応式
[Na].[P:2]([O:6][CH2:7][C@@H:8]([OH:13])[C@@H:9]([OH:12])[CH:10]=[O:11])([OH:5])([OH:4])=[O:3].[BH4-].[Na+]>CO>[P:2]([O:6][CH2:7][C@@H:8]([OH:13])[C@@H:9]([OH:12])[CH2:10][OH:11])([OH:4])([OH:5])=[O:3]

参加物

5

反応物 3

HCID 122357Erythrose, 4-phosphateHCID 4311764Sodium borohydrideHCID 5360545Sodium

生成物 1

HCID 192838D-erythritol 4-phosphate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The sodium salt of D-erythrose 4-phosphate (14.6 mg, 65.7 μmol) is dissolved in methanol (600 μl, 40% (v/v)). Sodium borohydride is added. The reaction is monitored by detection of the aldehyde according to the method of Stahl (Bollinger, H. R., Brenner, M., Gänshirt, H., Mangold, H. K., Seiler, H., Stahl, E. ad Waldi, D. (1964) IN: Dünnschicht-Chromatographie; Ein Laboratoriumshandbuch (ed. Stahl, E.) Springer Verlag, Berlin, Göttingen; Heidelberg). After consumption of the aidehyde the pH of the solution is adjusted with acetic acid to 4–5. The reaction mixture is lyophillized yielding D-erythritol 4-phosphate as a dry compound.

後処理

  1. customAfter consumption of the aidehyde the pH of the solution

出典と根拠

ORDレコード
ord-fa0f741e1a644be59ee09747885d4a0b
出典データセット
uspto-grants-2006_10
特許番号
US07122331B1

反応ノート

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