Ribose 5-phosphate → D-Ribitol 5-phosphate

HRID 1244186

反応式

HRID 1244186 の反応式
[Na].[P:2]([O:6][CH2:7][C@@H:8]([OH:15])[C@@H:9]([OH:14])[C@@H:10]([OH:13])[CH:11]=[O:12])([OH:5])([OH:4])=[O:3].[BH4-].[Na+]>CO>[P:2]([O:6][CH2:7][C@@H:8]([OH:15])[C@@H:9]([OH:14])[C@@H:10]([OH:13])[CH2:11][OH:12])([OH:4])([OH:5])=[O:3]

参加物

5

反応物 3

HCID 77982Ribose 5-phosphateHCID 4311764Sodium borohydrideHCID 5360545Sodium

生成物 1

HCID 151104D-Ribitol 5-phosphate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The sodium salt of D-ribose 5-phosphate (18.5 mg, 67.5 μmol) is dissolved in methanol (600 μl, 40% (v/v)). Sodium borohydride is added. The reaction is monitored by detection of the aldehyde according to the method of Stahl (Bollinger, H. R., Brenner, M., Gänshirt, H., Mangold, H. K., Seiler, H., Stahl, E. ad Waldi, D. (1964) IN: Dünnschicht-Chromatographie; Ein Laboratoriumshandbuch (ed. Stahl, E.) Springer Verlag, Berlin, Göttingen; Heidelberg). After consumption of the aldehyde the pH of the solution is adjusted with acetic acid to 4–5. The reaction mixture is lyophillized yielding D-ribitol 5-phosphate as a dry compound.

後処理

  1. customAfter consumption of the aldehyde the pH of the solution

出典と根拠

ORDレコード
ord-c0e5ce2d08bf4f2b9bc3ca9883ddf172
出典データセット
uspto-grants-2006_10
特許番号
US07122331B1

関連ノート

読み込み中…