Glycolic Acid → HCID 178423363、化合物

HRID 1244299ノート

反応式

HRID 1244299 の反応式
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[C:4]([CH3:9])[N:3]=1.[C:10](O)(=O)[CH2:11]O.S(Cl)([Cl:17])=O>C(Cl)(Cl)Cl>[ClH:17].[Cl:17][CH2:11][C:10]1[NH:1][C:2]2=[N:3][C:4]([CH3:9])=[CH:5][CH:6]=[C:7]2[N:8]=1

参加物

5

反応物 3

HCID 757Glycolic AcidHCID 24386Thionyl ChlorideHCID 27344206-Methylpyridine-2,3-diamine

生成物 1

HCID 178423363HCID 178423363、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

In accordance with scheme 4, a corresponding 2,3-diamino-6-methyl pyridine (R5=methyl, XV) and glycolic acid were heated at 150° C. for about 1 h. The residue was suspended in chloroform and treated with thionyl chloride for about 4 h. After workup 2-chloromethyl-5-methyl-3H-imidazo[4,5-b]pyridine hydrochloride (XVII) was obtained.

出典と根拠

ORDレコード
ord-d3fa850db4f44546a86a78d9daa1e420
出典データセット
uspto-grants-2006_10
特許番号
US07122545B2

反応ノート

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