Sodium Hydroxide → 4-Methyl-5-naphthalen-1-yl-thiazole-2-carboxylic acid

HRID 12453

反応式

HRID 12453 の反応式
C([O:3][C:4]([C:6]1[S:7][C:8]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=2)=[C:9]([CH3:11])[N:10]=1)=[O:5])C.[OH-].[Na+]>O.C1COCC1>[CH3:11][C:9]1[N:10]=[C:6]([C:4]([OH:5])=[O:3])[S:7][C:8]=1[C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 593384494-Methyl-5-naphthalen-1-yl-thiazole-2-carboxylic acid ethyl ester

生成物 1

HCID 593378204-Methyl-5-naphthalen-1-yl-thiazole-2-carboxylic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 4-methyl-5-naphthalen-1-yl-thiazole-2-carboxylic acid ethyl ester (30 mg, 0.10 mmol) in water (1 ml) and THF (1 ml) is added sodium hydroxide (0.2 mL, 1M, 0.20 mmol). The reaction mixture is stirred at rt for 1 hr, and then extracted with ethyl ether (30 mL). The aqueous layer is acidified to pH<7.0 by phosphate buffer and then extracted with EtOAc (2×50 mL). The combined organic layers are washed with brine, dried over MgSO4, and then concentrated. The crude product is used in the next step without further purification.

後処理

  1. extractionextracted with ethyl ether (30 mL)
  2. extractionextracted with EtOAc (2×50 mL)
  3. washThe combined organic layers are washed with brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated
  6. customThe crude product is used in the next step without further purification

出典と根拠

ORDレコード
ord-a99f6adcd06645219a6b3df332299ba2
出典データセット
uspto-grants-2010_06
特許番号
US07728009B1

関連ノート

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