Iodoethane → 2-(Ethylthio)-5-methoxypyrimidine-4,6(1H,5H)-dione
反応式
[CH2:1](I)[CH3:2].[CH3:4][O:5][CH:6]1[C:11](=[O:12])[NH:10][C:9](=[S:13])[NH:8][C:7]1=[O:14].[OH-].[Na+]>O>[CH2:1]([S:13][C:9]1[NH:8][C:7](=[O:14])[CH:6]([O:5][CH3:4])[C:11](=[O:12])[N:10]=1)[CH3:2]参加物
5
実験手順
Ethyl iodide (11.2 ml) was added dropwise to a stirred mixture of the product from step (i) (23 g) and sodium hydroxide (6 g) in water (400 ml). After 16 h the mixture was filtered, the filtrate acidified to pH1 and the precipitate filtered, washed with water and dried. Yield 17.8 g
後処理
- filtrationAfter 16 h the mixture was filtered
- filtrationthe precipitate filtered
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-7e54e2529ee5435eba8ed70b5e3726f1
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07125881B2
反応ノート
読み込み中…