1-Methylpiperazine → HCID 10133945、化合物
反応式
[NH2:1][C:2]([NH:4][C:5]1[S:6][C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH:19]=O)=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])=[O:3].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].[CH3:35][N:36]1[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1>O1CCCC1>[NH2:1][C:2]([NH:4][C:5]1[S:6][C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH2:19][N:39]2[CH2:40][CH2:41][N:36]([CH3:35])[CH2:37][CH2:38]2)=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])=[O:3]参加物
5
実験手順
2-[(Aminocarbonyl)amino]-5-[2-formylphenyl]-3-thiophenecarboxamide (0.1 g) and sodium tri-acetoxy borohydride (0.1 g) were mixed with tetrahydrofuran (10 ml). N-Methylpiperazine (0.04 g) was added and the mixture stirred at room temperature for 18 h. Separation was achieved using cation exchange chromatography eluting with ammonia/methanol/dichloromethane mixtures. This gave the title compound (0.07 g).