Lithium Hydroxide → 1-Ethyl-2-(naphthalen-1-yl)-1H-imidazole-4-carboxylic acid

HRID 12460ノート

反応式

HRID 12460 の反応式
C([O:3][C:4]([C:6]1[N:7]=[C:8]([C:13]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=[CH:15][CH:14]=2)[N:9]([CH2:11][CH3:12])[CH:10]=1)=[O:5])C.[OH-].[Li+]>C1COCC1.O>[CH2:11]([N:9]1[CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=[C:8]1[C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1)[CH3:12]

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 686285741-ethyl-2-naphthalen-1-yl-1H-imidazole-4-carboxylic acid ethyl ester

生成物 1

HCID 534224541-Ethyl-2-(naphthalen-1-yl)-1H-imidazole-4-carboxylic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
50 °C

実験手順

1-Ethyl-2-naphthalen-1-yl-1H-imidazole-4-carboxylic acid ethyl ester (2.2 g, 7.48 mmol) is dissolved in THF (20 ml), followed by the addition of aqueous lithium hydroxide solution (2.0 N, 7.5 ml, 2.0 eq.). The mixture is heated at 50° C. overnight. THF is stripped off under reduced pressure, and the residue is diluted with water (10 ml), basified to pH=4˜5. The solid precipitate is collected, washed with water and ether, dried under high vacuum to give the title compound. LCMS 267 (M+1).

後処理

  1. customThe solid precipitate is collected
  2. washwashed with water and ether
  3. customdried under high vacuum

出典と根拠

ORDレコード
ord-e1d19fefd1aa46a38ad1627104fb90fd
出典データセット
uspto-grants-2010_06
特許番号
US07728009B1

反応ノート

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