Dimethylformamide → HCID 21914741、化合物

HRID 1246500

反応式

HRID 1246500 の反応式
[SH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([OH:12])=O)=[CH:4][CH:3]=1.[C:13]([O-])([O-])=O.[K+].[K+].IC.CN([CH:24]=[O:25])C>>[CH3:13][S:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([O:25][CH3:24])=[O:12])=[CH:4][CH:3]=1

参加物

5

反応物 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 5797844-Mercaptohydrocinnamic Acid

生成物 1

HCID 21914741HCID 21914741、化合物

実験手順

3-(4-Mercaptophenyl)propanoic acid (5 g), K2CO3 (11.4 g) and DMF (30 ml) were combined, and iodomethane (5.12 ml) was added dropwise to the mixture at 0° C. under N2 atmosphere. The reaction mixture was stirred at r.t. for 13 hours, and poured into ice-water. The mixture was extracted with AcOEt. The organic layer was washed with water (twice) and brine, dried over anhydrous MgSO4, and concentrated in vacuo to give methyl 3-[4-(methylthio)phenyl]propanoate (4.19 g) as pale yellow oil.

後処理

  1. extractionThe mixture was extracted with AcOEt
  2. washThe organic layer was washed with water (twice) and brine
  3. dry with materialdried over anhydrous MgSO4
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-e1431242c31c4268b8a737787ecd2602
出典データセット
uspto-grants-2006_10
特許番号
US07125901B2

関連ノート

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