Dichloromethane → methyl N-butanimidoylcarbamate

HRID 1248101ノート

反応式

HRID 1248101 の反応式
Cl[C:2]([O:4][CH3:5])=[O:3].[OH-].[Na+].Cl.[C:9]([NH2:14])(=[NH:13])[CH2:10][CH2:11][CH3:12].C(Cl)Cl>O>[CH3:5][O:4][C:2]([NH:14][C:9](=[NH:13])[CH2:10][CH2:11][CH3:12])=[O:3]

参加物

6

反応物 4

HCID 6344DichloromethaneHCID 6586Methyl chloroformateHCID 14798Sodium HydroxideHCID 12828983Butanimidamide hydrochloride

生成物 1

HCID 140338858methyl N-butanimidoylcarbamate収率 95%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

222 parts of methyl chloroformate and 337 parts of 50% strength sodium hydroxide solution are added via two inlets to a mixture of 286 parts of butyramidine hydrochloride in 1,300 parts of methylene chloride and 500 parts of water, at from 10° to 15° C., in the course of 25 minutes, while stirring. The mixture is stirred at room temperature for 2 hours, and the organic phase is separated off and concentrated on a rotary evaporator to give 320 parts (95% of theory) of N-methoxycarbonylbutyramidine of nD25 1.4763.

後処理

  1. stirringThe mixture is stirred at room temperature for 2 hours
  2. customthe organic phase is separated off
  3. concentrationconcentrated on a rotary evaporator

出典と根拠

ORDレコード
ord-fb794d0d9bf345cba7468b81bd50068a
出典データセット
uspto-grants-1985_06
特許番号
US04522763

反応ノート

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