Methyl iodide → HCID 13330684、化合物

HRID 1248417ノート

反応式

HRID 1248417 の反応式
[CH3:1]I.[CH2:3]([C:7]1[C:8](=[O:14])[NH:9][C:10](=[S:13])[NH:11][CH:12]=1)[CH2:4][CH2:5][CH3:6].[OH-].[Na+]>O.C(O)C>[CH2:3]([C:7]1[C:8](=[O:14])[NH:9][C:10]([S:13][CH3:1])=[N:11][CH:12]=1)[CH2:4][CH2:5][CH3:6]

参加物

6

反応物 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 133306795-Butyl-2-thiouracil

生成物 1

HCID 13330684HCID 13330684、化合物収率 25.2%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

Methyl iodide (2.74 g) was added to a stirred solution of 5-butyl-2,3-dihydro-2-thioxo-4(1H)-pyrimidinone (3.5 g) and sodium hydroxide (0.78 g) in water (10 ml) and ethanol (20 ml) at room temperature and heated at 70° for 45 minutes. The solid which separated on standing was filtered and washed with ethanol and water to give the title compound (0.95 g) m.p. 138°-140.5°.

後処理

  1. temperatureheated at 70° for 45 minutes
  2. customThe solid which separated on standing
  3. filtrationwas filtered
  4. washwashed with ethanol and water

出典と根拠

ORDレコード
ord-053c4bfa0cce4b29923a02989066da47
出典データセット
uspto-grants-1985_06
特許番号
US04524071

反応ノート

読み込み中…