Water → 4-hydroxy-1H-1,2-benzisothiazole-1,1,3(2H)-trione

HRID 1248780

反応式

HRID 1248780 の反応式
[S:1]1(=[O:12])(=[O:11])[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3](=[O:10])[NH:2]1.FC(F)(F)C([O-])=[O:16].[Na+].O>FC(F)(F)C(O)=O>[OH:16][C:9]1[C:4]2[C:3](=[O:10])[NH:2][S:1](=[O:11])(=[O:12])[C:5]=2[CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 962WaterHCID 5143SaccharinHCID 517019Sodium Trifluoroacetate

生成物 1

HCID 14865224-hydroxy-1H-1,2-benzisothiazole-1,1,3(2H)-trione収率 61%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

4.6 g (25 mmol) of 1,2-benzisothiazol-3(2H)-one-1,1-dioxide (Saccharin®) were dissolved in 30 ml of trifluoroacetic acid and mixed with 4 g of sodium trifluoroacetate. The solution was electrolysed analogously to Example 1. After a charge quantity of 0.4 Ah had been used up the solution was added to water. It was extracted with chloroform and worked up as in Example 1. In addition to 3.3 g of starting material, 0.92 g of 4-hydroxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide were obtained after recrystallisation from water. This corresponds to a yield of 61% based on the starting material reacted;

後処理

  1. extractionIt was extracted with chloroform
  2. additionIn addition to 3.3 g of starting material

出典と根拠

ORDレコード
ord-2a16ac6880be4a4eb206566ad2b4e1c3
出典データセット
uspto-grants-1986_12
特許番号
US04626325

関連ノート

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