Hydrazine hydrate (1:1) → 3,3a,4,5,6,7-hexahydro-2H-indazole

HRID 12488

反応式

HRID 12488 の反応式
O.[NH2:2]N.C[N:5]([CH2:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C:9]1=O)C>CCCCO>[N:2]1[NH:5][CH2:7][CH:8]2[C:9]=1[CH2:10][CH2:11][CH2:12][CH2:13]2

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 858382-((Dimethylamino)methyl)cyclohexanone

生成物 1

HCID 593393383,3a,4,5,6,7-hexahydro-2H-indazole

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒2 回

実験手順

Hydrazine hydrate (28.0 mL) was dissolved in n-BuOH (200 mL) and cooled in an ice bath. A solution of 2-dimethylaminomethyl-cyclohexanone (64.0 g) in n-BuOH (50 mL) was added dropwise, the mixture was slowly warmed and refluxed for 20 hours. The solvent was evaporated under reduced pressure.

後処理

  1. temperaturecooled in an ice bath
  2. temperaturethe mixture was slowly warmed
  3. temperaturerefluxed for 20 hours
  4. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-d60c876a3fb140c791fbe1953581d169
出典データセット
uspto-grants-2010_06
特許番号
US07728018B2

関連ノート

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