Trimethylsilyl cyanide → 2-(3-Bromophenyl)-2-methoxyethan-1-amine

HRID 1249208ノート

反応式

HRID 1249208 の反応式
CO[CH:3]([O:11][CH3:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Br:10])[CH:5]=1.C[Si]([C:17]#[N:18])(C)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>[I-].[Zn+2].[I-].C(#N)C>[CH3:12][O:11][CH:3]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Br:10])[CH:5]=1)[CH2:17][NH2:18]

参加物

6

反応物 3

HCID 82115Trimethylsilyl cyanideHCID 1053951-Bromo-3-(dimethoxymethyl)benzeneHCID 21226445Aluminium lithium hydride

生成物 1

HCID 202252042-(3-Bromophenyl)-2-methoxyethan-1-amine

試薬・触媒・溶媒 2

HCID 9883512zinc(II)iodide触媒HCID 6342Acetonitrile溶媒

実験手順

1-Methoxy-1-(3-bromophenyl)acetonitrile was prepared from 3-bromobenzaldehyde dimethyl acetal and trimethylsilyl cyanide, using zinc iodide as catalyst, by an analogous procedure to that described in Example X1. Reduction of the acetonitrile with lithium aluminium hydride by an analogous procedure to that described in Example X2 gave the title compound.

出典と根拠

ORDレコード
ord-9cc7b076408d44caa43e11ed6f07988e
出典データセット
uspto-grants-1986_12
特許番号
US04629737

反応ノート

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