Sodium Hydroxide → 8-Hydroxyquinoline

HRID 1249644ノート

反応式

HRID 1249644 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2S([O-])(=O)=O)[CH:4]=[CH:3][CH:2]=1.[Na+].[OH-:16].[Na+]>O>[OH:16][C:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[N:1]=[CH:2][CH:3]=[CH:4]2

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 23669146Sodium quinoline-8-sulfonate

生成物 1

HCID 19238-Hydroxyquinoline収率 97.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Sodium quinoline-8-sulfonate (231 g) was added to 170 g of a 50% aqueous solution of sodium hydroxide, and the mixture was stirred. Then, 900 g of a hydrogenated triphenyl mixture was mixed, and the mixture was dehydrated. The dehydrated mixture was reacted at 260° C. for 15 minutes in a nitrogen stream. After cooling, 600 ml of water was added to the reaction mixture to separate the reaction medium layer. The aqueous layer was decolorized with activated carbon, acidified and then extracted with 200 ml of chloroform. The chloroform was recovered to give 140.9 g (yield 97.2%) of 8-hydroxyquinoline.

後処理

  1. customThe dehydrated mixture was reacted at 260° C. for 15 minutes in a nitrogen stream
  2. temperatureAfter cooling
  3. customto separate the reaction medium layer
  4. extractionextracted with 200 ml of chloroform
  5. customThe chloroform was recovered

出典と根拠

ORDレコード
ord-598777ab442c45c7ac24497548efd2a9
出典データセット
uspto-grants-1986_12
特許番号
US04633024

反応ノート

読み込み中…