Water → 4-(Hydroxymethyl)-3-methylbenzonitrile
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[CH:10]=C)[C:5]#[N:6].[O:12]=[O+][O-].[BH4-].[Na+].O>CO>[OH:12][CH2:10][C:9]1[CH:8]=[CH:7][C:4]([C:5]#[N:6])=[CH:3][C:2]=1[CH3:1]参加物
6
反応条件
- 温度
- -70 °C
実験手順
3-Methyl-4-vinylbenzonitrile (0.40 g; 2.8 mmol; from step (i) above) was dissolved in 50 mL of methanol and cooled to −70° C. Ozone (2 eq.) was bubbled through, and then 0.20 g (5.3 mmol) of sodium borohydride and 5 mL of water were added and the cooling bath was removed. After 4 h the methanol was evaporated and the residue was partitioned between 1M HCl and ether. The aqueous layer was extracted twice with ether and the combined organic phase was washed with water, dried (Na2SO4) and evaporated to yield 0.37 g (90%) of the desired product, which was used in the next step without further purification.
後処理
- additionwere added
- customthe cooling bath was removed
- customAfter 4 h the methanol was evaporated
- customthe residue was partitioned between 1M HCl and ether
- extractionThe aqueous layer was extracted twice with ether
- washthe combined organic phase was washed with water
- dry with materialdried (Na2SO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-6aa23f0416354da883ddf147d9477e39
- 出典データセット
- uspto-grants-2002_01
- 特許番号
- US06337394B2
反応ノート
読み込み中…