Hydrochloric Acid → 9-(1,3-Benzodioxol-5-yl)-8-methyl-benzo[g][1,3]benzodioxole-7-carboxylic acid

HRID 1250941ノート

反応式

HRID 1250941 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:11]([CH3:27])=[C:12]([C:23]([O:25]C)=[O:24])[CH:13]=[C:14]4[C:22]=3[C:18]3[O:19][CH2:20][O:21][C:17]=3[CH:16]=[CH:15]4)=[CH:9][C:4]=2[O:3][CH2:2]1.[OH-].[Na+].Cl.O>C1COCC1.CO>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:11]([CH3:27])=[C:12]([C:23]([OH:25])=[O:24])[CH:13]=[C:14]4[C:22]=3[C:18]3[O:19][CH2:20][O:21][C:17]=3[CH:16]=[CH:15]4)=[CH:9][C:4]=2[O:3][CH2:2]1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 18325127HCID 18325127、化合物

生成物 1

HCID 4931639-(1,3-Benzodioxol-5-yl)-8-methyl-benzo[g][1,3]benzodioxole-7-carboxylic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

Methyl 9-(1,3-benzodioxole-5-yl)-8-methyl-naphtho[1,2-d]-1,3-dioxole-7-carboxylate was dissolved in a mixture of THF (6 ml) and methanol (3 ml). After addition of 1N NaOH (3 ml), the mixture was stirred for 4 days. 1N HCl was added to the reaction mixture, followed by addition of water. The resulting precipitate was collected by filtration to yield the title compound (264 mg). Some portions of the compound was recrystalized from methanol-chloroform to be used for elemental and instrumental analysis.

後処理

  1. filtrationThe resulting precipitate was collected by filtration

出典と根拠

ORDレコード
ord-acb9eb33aa014aba95c716d86a5097d3
出典データセット
uspto-grants-2002_01
特許番号
US06340704B1

反応ノート

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