反応式
[O:1]1CCCC1.[Si:6]([O:13][C@@H:14]([C@@H:16]1[C@@H:19]([C@@H:20]([CH3:40])[C:21](C2C=C(C)C=CC=2S(NC2CCCCC2)(=O)=O)=[O:22])[NH:18][C:17]1=[O:41])[CH3:15])([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7].[OH-].[Na+]>O>[Si:6]([O:13][C@@H:14]([C@@H:16]1[C@@H:19]([C@@H:20]([CH3:40])[C:21]([OH:22])=[O:1])[NH:18][C:17]1=[O:41])[CH3:15])([C:9]([CH3:10])([CH3:11])[CH3:12])([CH3:7])[CH3:8]参加物
5
反応物 3
生成物 1
試薬・触媒・溶媒 1
実験手順
To a tetrahydrofuran solution (2:1, 3.5 ml) of 3-{(2R)-2-[(3S,4R)-3-[(1R)-1-tert-butyldimethylsilyloxyethyl]-2-oxoazetidin-4-yl]propionyl}-N-cyclohexyl-p-toluenesulfonamide (218 mg, 0.4 mmol, β:α=88:12), 0.5N aqueous sodium hydroxide (1.8 ml) was added dropwise at room temperature, followed by stirring for 3 hours at the same temperature. To the reaction mixture, 5 ml of water was then poured and the resulting mixture was washed with methylene chloride. The aqueous layer was acidified to pH 2 with 2N-hydrochloric acid. The crystals so precipitated were collected by filtration, washed with water, and then dried under reduced pressure, whereby 84 mg (β:α=89:11) of the colorless title compound was obtained (yield: 69%).
後処理
- washthe resulting mixture was washed with methylene chloride
- customThe crystals so precipitated
- filtrationwere collected by filtration
- washwashed with water
- dry with materialdried under reduced pressure, whereby 84 mg (β:α=89:11) of the colorless title compound
- customwas obtained (yield: 69%)
出典と根拠
- ORDレコード
- ord-fa2d71596bca4bbe9866ba64597d5054
- 出典データセット
- uspto-grants-2002_01
- 特許番号
- US06340751B1
関連ノート
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