Sodium Hydroxide → HCID 9856593、化合物

HRID 1251008ノート

反応式

HRID 1251008 の反応式
[CH3:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:9]2[NH:8][C:7](=[O:15])[C:6](=[O:16])[NH:5][C:4]=2[C:3]=1[C:17]([O:19]C)=[O:18].[OH-].[Na+]>C1COCC1>[CH3:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:9]2[NH:8][C:7](=[O:15])[C:6](=[O:16])[NH:5][C:4]=2[C:3]=1[C:17]([OH:19])=[O:18]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 10588717HCID 10588717、化合物

生成物 1

HCID 9856593HCID 9856593、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a suspension of 6-methyl-7-nitro-2,3-dioxo-1,2,3,4-tetrahydro-quinoxaline-5-carboxylic acid, methyl ester (0.80 g, 2.87 mmol) in THF (50 mL) was added aqueous 1.0N NaOH (4.3 mL, 4.3 mmol), and the reaction mixture was refluxed for 23 hours. The product is precipitated upon acidification with conc. HCL and recrystallized from water to give 0.73 g (96%).

後処理

  1. temperaturethe reaction mixture was refluxed for 23 hours
  2. customThe product is precipitated upon acidification with conc. HCL
  3. customrecrystallized from water
  4. customto give 0.73 g (96%)

出典と根拠

ORDレコード
ord-54e8e249a5524c0ca6c8a7aa9db7991b
出典データセット
uspto-grants-2002_01
特許番号
US06340758B1

反応ノート

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