3-(1-Naphthalenyl)-2-propenoic acid → 1-Naphthalenepropionic acid

HRID 1251572ノート

反応式

HRID 1251572 の反応式
[C:1]1([CH:11]=[CH:12][C:13]([OH:15])=[O:14])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1>[Pd].O1CCCC1>[C:1]1([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 1

HCID 983073-(1-Naphthalenyl)-2-propenoic acid

生成物 1

HCID 952541-Naphthalenepropionic acid収率 99%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

10% Palladium on carbon (1.00 g) was added to a suspension of 3-(1-naphthyl)acrylic acid (50.0 g) in tetrahydrofuran (500 ml). The mixture was hydrogenated at 6 atmospheres for 18 hours then filtered through a kieselguhr pad washing with ethyl acetate (3×100 ml). The filtrate was evaporated under reduced pressure to give the subtitle compound (50.0 g) as a solid.

後処理

  1. filtrationthen filtered through a kieselguhr pad
  2. washwashing with ethyl acetate (3×100 ml)
  3. customThe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-a1541808a78944e0adcdf029d0a9eb90
出典データセット
uspto-grants-2002_01
特許番号
US06342502B1

反応ノート

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