Chlorosulfonic acid → HCID 22998500、化合物
反応式
[CH2:1]([C:8]1[S:9][CH:10]=[CH:11][CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[S:14]([OH:17])(=[O:16])=[O:15]>C(Cl)(Cl)Cl>[CH2:1]([C:8]1[S:9][C:10]([S:14]([OH:17])(=[O:16])=[O:15])=[CH:11][CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a solution of 2-benzylthiophene (0.875 g, 5 mmol) in chloroform (2 ml) at 0° C. was added chlorosulfonic acid dropwise and the reaction was stirred at 0° C. for 30 min. The reaction mixture was decomposed by pouring onto crushed ice (20 g). The mixture was extracted with ethyl acetate, dried over MgSO4 and filtered. The solvent was removed under reduced pressure to give 5-benzylthiophene-2-sulfonic acid.
後処理
- additionby pouring
- extractionThe mixture was extracted with ethyl acetate
- dry with materialdried over MgSO4
- filtrationfiltered
- customThe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-9ee04fb51b7f4cd2a0de43ec16554ee7
- 出典データセット
- uspto-grants-2002_01
- 特許番号
- US06342610B2
反応ノート
読み込み中…