Tetrahydrofuran → HCID 10976559、化合物

HRID 1251960ノート

反応式

HRID 1251960 の反応式
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[C:6](=[O:14])[CH2:7][C:8]2=[O:13])([O-])=O.[H][H].[O:17]1CC[CH2:19][CH2:18]1>C(O)C.[Pd]>[C:18]([CH:7]1[C:6](=[O:14])[C:5]2[C:9](=[CH:10][CH:11]=[CH:12][C:4]=2[NH2:1])[C:8]1=[O:13])(=[O:17])[CH3:19]

参加物

6

反応物 3

HCID 8028TetrahydrofuranHCID 27370564-Nitro-1H-indene-1,3(2H)-dioneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 10976559HCID 10976559、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a suspension of 20.0 g of 4-nitro-1,3-indanedione in 100 mL tetrahydrofuran and 20 mL of ethanol, 1.0 g of 10% Pd/C catalyst was added and the mixture hydrogenated at 50 psi until three molar equivalents of hydrogen were taken up. The catalyst was filtered off and solvent was removed from the filtrate under reduced pressure. Recrystallization from ethanol afforded 14.8 g of the title compound, m.p. 126°-128°.

後処理

  1. additionwas added
  2. filtrationThe catalyst was filtered off
  3. customsolvent was removed from the filtrate under reduced pressure
  4. customRecrystallization from ethanol

出典と根拠

ORDレコード
ord-730cc5b51ac84efabced969db7e8e437
出典データセット
uspto-grants-1988_05
特許番号
US04741765

反応ノート

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