Sodium Sulfite → 4-p-Methoxybenzyloxycarbonyl-4-methylvaleric acid

HRID 1252218ノート

反応式

HRID 1252218 の反応式
S([O-])([O-])=O.[Na+].[Na+].[CH3:7][O:8][C:9]1[CH:36]=[CH:35][C:12]([CH2:13][O:14][C:15]([C:17]([CH3:34])([CH3:33])[CH2:18][CH2:19][C:20]([O:22]CC2C=CC([N+]([O-])=O)=CC=2)=[O:21])=[O:16])=[CH:11][CH:10]=1>O.O1CCCC1>[CH3:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:13][O:14][C:15]([C:17]([CH3:33])([CH3:34])[CH2:18][CH2:19][C:20]([OH:22])=[O:21])=[O:16])=[CH:35][CH:36]=1

参加物

5

反応物 2

HCID 24437Sodium SulfiteHCID 20140840p-Nitrobenzyl 4-p-methoxybenzyloxycarbonyl-4-methylvalerate

生成物 1

HCID 141557204-p-Methoxybenzyloxycarbonyl-4-methylvaleric acid

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of sodium sulfite hydrade (12.35 g) in water (70 ml) was added a solution of p-nitrobenzyl 4-p-methoxybenzyloxycarbonyl-4-methylvalerate (25.4 g) in tetrahydrofuran (140 ml). The reaction mixture was stirred at room temperature for 7.5 hours, diluted with water and washed with diethyl ether. The aqueous layer was acidified with hydrochloric acid and extracted with diethyl ether. The extract was washed with water, dried over anhydrous sodium sulfate and evaporated to give 4-p-methoxybenzyloxycarbonyl-4-methylvaleric acid.

後処理

  1. washwashed with diethyl ether
  2. extractionextracted with diethyl ether
  3. washThe extract was washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customevaporated

出典と根拠

ORDレコード
ord-78dd7377fb6a46e2813f08950e124011
出典データセット
uspto-grants-1988_05
特許番号
US04742052

反応ノート

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