Hydrochloric Acid → Benzoyl chloride

HRID 1253435ノート

反応式

HRID 1253435 の反応式
[C:1]1([C:7]2[O:8]C3C=C(C(O)=O)C=CC=3N=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(C2OC3C=C(C(OC)=O)C=CC=3N=2)C=CC=CC=1.[Li+].[OH-].[ClH:40]>C1COCC1.CO.O>[C:7]([Cl:40])(=[O:8])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

8

反応物 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 10586965Methyl 2-phenyl-benzoxazole-6-carboxylateHCID 109007142-Phenyl-1,3-benzoxazole-6-carboxylic acid

生成物 1

HCID 7412Benzoyl chloride

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

2-Phenyl-benzooxazole-6-carboxylic acid, 1v. A mixture of methyl 2-phenyl-benzooxazole-6-carboxylate 1u (0.37 g, 1.46 mmol) and LiOH (0.10 g, 4.2 mmol) in THF (4 mL), MeOH (4 mL), and H2O (4 mL) was stirred at room temperature for 6 h. Aqueous 1N HCl solution was added to the mixture to adjust pH to 3-4. The resulting mixture was extracted with EtOAc (2×). The organic solution was washed with aq. NaCl, dried over Na2SO4 and concentrated to give 1t (0.34 g).

後処理

  1. extractionThe resulting mixture was extracted with EtOAc (2×)
  2. washThe organic solution was washed with aq. NaCl
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-0b4b747d3b6e41f18987ed26d8727b03
出典データセット
uspto-grants-2013_06
特許番号
US08455476B2

反応ノート

読み込み中…