Hydrogen Bromide → HCID 67207447、化合物

HRID 1253539ノート

反応式

HRID 1253539 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([O:11]C)[C:5]2[N:6]([N:8]=[CH:9][CH:10]=2)[CH:7]=1.Br.[OH-].[Na+]>O.C(OCC)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([OH:11])[C:5]2[N:6]([N:8]=[CH:9][CH:10]=2)[CH:7]=1

参加物

6

反応物 3

HCID 260Hydrogen BromideHCID 14798Sodium HydroxideHCID 446228256-Bromo-4-methoxypyrazolo[1,5-a]pyridine

生成物 1

HCID 67207447HCID 67207447、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
150 °C

実験手順

6-bromo-4-methoxypyrazolo[1,5-a]pyridine (1.50 g, 6.61 mmol) was suspended in HBr (15 ml, 133 mmol). The reaction mixture was heated in the Biotage Initiator Series microwave for 80 minutes at 150° C. The reaction mixture was added dropwise via pipette to a mixture of NaOH (5.29 g, 132 mmol) in 50 mL of water and ice. The mixture was diluted in ethyl acetate, washed with saturated aqueous sodium bicarbonate and brine then dried over sodium sulfate, filtered and concentrated to give 6-bromopyrazolo[1,5-a]pyridin-4-ol.

後処理

  1. washwashed with saturated aqueous sodium bicarbonate and brine
  2. dry with materialthen dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-f7583cc29d5647949bc680136988c357
出典データセット
uspto-grants-2013_06
特許番号
US08455477B2

反応ノート

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