m-Chloroperbenzoic acid → HCID 67314368、化合物

HRID 1254083ノート

反応式

HRID 1254083 の反応式
[CH3:1][C:2]1[N:7]=[C:6]2[CH2:8][O:9][C:10](=[O:11])[C:5]2=[CH:4][CH:3]=1.ClC1C=C(C=CC=1)C(OO)=[O:17]>C(Cl)(Cl)Cl.ClCCl>[CH3:1][C:2]1[N+:7]([O-:17])=[C:6]2[CH2:8][O:9][C:10](=[O:11])[C:5]2=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 58478770HCID 58478770、化合物

生成物 1

HCID 67314368HCID 67314368、化合物収率 73.9%

試薬・触媒・溶媒 2

HCID 6212Chloroform溶媒HCID 6344Dichloromethane溶媒

実験手順

A solution of 2-methyl-7H-furo[3,4-b]pyridin-5-one (150 mg, 1.0 mmol) in chloroform (5 mL) and dichloromethane (1 mL) is treated with m-chloroperoxybenzoic acid (258 mg, 1.5 mmol). The reaction mixture is stirred at room temperature overnight. The reaction mixture is concentrated and the residue is purified by chromatography (silica gel). The product containing fractions are concentrated to give the title compound as a solid (122 mg, 73%).

後処理

  1. concentrationThe reaction mixture is concentrated
  2. customthe residue is purified by chromatography (silica gel)
  3. additionThe product containing fractions
  4. concentrationare concentrated

出典と根拠

ORDレコード
ord-c69c06a9357844abb74d7c552645d600
出典データセット
uspto-grants-2013_06
特許番号
US08455535B2

反応ノート

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