N-bromobutanimide → Methyl 2-bromo-2-(2-fluorophenyl)acetate

HRID 1255090ノート

反応式

HRID 1255090 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([O:11][CH3:12])=[O:10].[Br:13]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C(Cl)Cl.Br>[CH3:12][O:11][C:9](=[O:10])[CH:8]([Br:13])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[F:1]

参加物

6

反応物 2

HCID 67184N-bromobutanimideHCID 2733230Methyl 2-fluorophenylacetate

生成物 1

HCID 18004644Methyl 2-bromo-2-(2-fluorophenyl)acetate収率 100%

試薬・触媒・溶媒 3

HCID 260Hydrogen Bromide触媒HCID 5943Carbon Tetrachloride溶媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of methyl 2-(2-fluorophenyl)acetate (1.0 g, 5.95 mmol) in CCl4 (15 mL), are added N-bromo succinimide (1.06 g, 5.95 mmol) and 48% hydrogen bromide (33 uL, 0.30 mmol) and the reaction is refluxed for 15 hours. Reaction is diluted with DCM and washed with Na2CO3 and water. The organic phase is dried over Na2SO4, filtered and evaporated under vacuum to afford intermediate I261 as a dark brown oil (1.47 g, quantitative yield).

後処理

  1. temperaturethe reaction is refluxed for 15 hours
  2. customReaction
  3. washwashed with Na2CO3 and water
  4. dry with materialThe organic phase is dried over Na2SO4
  5. filtrationfiltered
  6. customevaporated under vacuum

出典と根拠

ORDレコード
ord-00c0266630d54085bd1d4b1b7331e30b
出典データセット
uspto-grants-2013_06
特許番号
US08455646B2

反応ノート

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