Hydrochloric Acid → HCID 66939369、化合物

HRID 1257413ノート

反応式

HRID 1257413 の反応式
[F:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1[O:13][CH:14]=[C:15]([CH2:17][N:18]2[CH:22]=[C:21]([C:23]([O:25]CC)=[O:24])[CH:20]=[N:19]2)[N:16]=1.[OH-].[Na+].C(O)C.Cl>O1CCCC1>[F:1][C:2]1[C:7]([C:8]([F:9])([F:10])[F:11])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1[O:13][CH:14]=[C:15]([CH2:17][N:18]2[CH:22]=[C:21]([C:23]([OH:25])=[O:24])[CH:20]=[N:19]2)[N:16]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 66939284HCID 66939284、化合物

生成物 1

HCID 66939369HCID 66939369、化合物収率 78.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of the compound (0.44 g) obtained in Example 105b, 4N sodium hydroxide (3 mL), ethanol (8 mL) and tetrahydrofuran (2 mL) was stirred at room temperature for 16 hr. The reaction mixture was adjusted to pH 5 with 1N hydrochloric acid, and the precipitate was collected by filtration, dried under reduced pressure and recrystallized from ethanol-hexane to give the title compound (0.32 g) as colorless crystals.

後処理

  1. filtrationthe precipitate was collected by filtration
  2. customdried under reduced pressure
  3. customrecrystallized from ethanol-hexane

出典と根拠

ORDレコード
ord-9fd40d7fff4648aa8b54e4489c064a35
出典データセット
uspto-grants-2013_06
特許番号
US08461348B2

反応ノート

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