4-Chloro-5-(3,3-difluoropyrrolidin-1-yl)-2-nitroaniline → 4-Chloro-5-(3,3-difluoropyrrolidin-1-yl)benzene-1,2-diamine dihydrochloride
反応式
[Cl:1][C:2]1[C:8]([N:9]2[CH2:13][CH2:12][C:11]([F:15])([F:14])[CH2:10]2)=[CH:7][C:5]([NH2:6])=[C:4]([N+:16]([O-])=O)[CH:3]=1>[Pd].C1COCC1>[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([NH2:16])[C:5]([NH2:6])=[CH:7][C:8]=1[N:9]1[CH2:13][CH2:12][C:11]([F:15])([F:14])[CH2:10]1参加物
4
実験手順
A mixture of 4-chloro-5-(3,3-difluoropyrrolidin-1-yl)-2-nitroaniline (300 mg, 1.1 mmol), THF (10 mL) and Pd/C (20 mg) was stirred for 1.5 days at RT under a hydrogen atmosphere (3.0 bar). The catalyst was removed by filtration. To the filtrate was added 4 M HCl in dioxane (10 mL). The mixture was concentrated and used in the next step without further purification.
後処理
- customThe catalyst was removed by filtration
- additionTo the filtrate was added 4 M HCl in dioxane (10 mL)
- concentrationThe mixture was concentrated
- customused in the next step without further purification
出典と根拠
- ORDレコード
- ord-d3a0e1a11a8c4d2ea6a32455eb846de4
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08466186B2
反応ノート
読み込み中…