Tetrahydrofuran → 5-Chloro-2-methylamino-4-(4-trifluoromethyl-piperidin-1-yl)aniline
反応式
[Cl:1][C:2]1[C:9]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]([F:19])([F:18])[F:17])[CH2:12][CH2:11]2)=[CH:8][C:5]([NH:6][CH3:7])=[C:4]([N+:20]([O-])=O)[CH:3]=1.C1COCC1>[Pt].CO>[Cl:1][C:2]1[C:9]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]([F:19])([F:18])[F:17])[CH2:12][CH2:11]2)=[CH:8][C:5]([NH:6][CH3:7])=[C:4]([CH:3]=1)[NH2:20]参加物
5
実験手順
A mixture of 4-chloro-N-methyl-2-nitro-5-(4-trifluoromethyl-piperidin-1-yl)aniline (1.07 g, 3.2 mmol), THF (20 mL), MeOH (30 mL) and Pt/C (100 mg) was stirred for 6 h at rt under a hydrogen atmosphere (3 bar). The catalyst was removed by filtration and the mixture was concentrated to give the sub-title compound.
後処理
- customThe catalyst was removed by filtration
- concentrationthe mixture was concentrated
出典と根拠
- ORDレコード
- ord-32e54dccf7194f78a479279bb11def23
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08466186B2
反応ノート
読み込み中…