反応式
[CH3:1][C:2](=[CH2:5])[CH2:3][OH:4].Br[CH2:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=1.[H-].[Na+].C(OCC1C=CC(C(O)=O)=CC=1)CC=C>>[CH3:5][C:2](=[CH2:1])[CH2:3][O:4][CH2:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=1参加物
5
実験手順
The reaction of 2-Methyl-prop-2-en-1-ol and 4-Bromomethyl-benzoic acid in the presence of sodium hydride was performed as described for Compound 33 to give 4-(2-Methyl-allyloxymethyl)benzoic acid as white powder. 1H-NMR (400 MHz, d6-DMSO): 12.85 (S, COOH); 7.91 (d, J=8.3, 2 arom. H); 7.42 (d, J=8.3, 2 arom.H); 4.96, 4.88 (2 s-like; C═CH2); 4.51 (s, —OCH2—C6H4); 3.90 (s, CH2O); 1.69 (s, CH3). 13C-NMR (100 MHz, d6-DMSO): 167.12 (—C═O); 143.60; 141.98; 129.74; 129.32 (2 arom.C); 127.09 (2 arom.C); 111.74; 73.50; 70.52; 19.29.
出典と根拠
- ORDレコード
- ord-1ffdd83029574df5b980b582d2fa0106
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08466199B2
関連ノート
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