Pyridine → 3-Chloro-5-(trifluoromethyl)picolinaldehyde oxime
反応式
[Cl:1][C:2]1[C:3]([CH:12]=O)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.Cl.[NH2:15][OH:16].N1C=CC=CC=1>C(O)C.C(OCC)(=O)C.O>[Cl:1][C:2]1[C:3]([CH:12]=[N:15][OH:16])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1参加物
7
実験手順
A solution of 3-chloro-5-(trifluoromethyl)picolinaldehyde (1.0 eq.), hydroxylamine hydrochloride (5.0 eq.), and pyridine (4.0 eq.) in ethanol was heated to 95° C. and stirred for 1 hour. The reaction was cooled to room temperature and diluted with ethyl acetate and water. The organic layer was washed with brine, water, dried over anhydrous MgSO4, and concentrated en vacuo to give a solid that was carried onto the next step without further purification.
後処理
- washThe organic layer was washed with brine, water
- dry with materialdried over anhydrous MgSO4
- concentrationconcentrated en vacuo
- customto give a solid
- customthat was carried onto the next step without further purification
出典と根拠
- ORDレコード
- ord-14c141f09dad42bc8fae973638191d19
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08466167B2
反応ノート
読み込み中…